Antibody‐Independent Activation of the Classical Complement Pathway by Cytomegalovirus‐Infected Fibroblasts

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Antibody-independent activation of the classical complement pathway by cytomegalovirus-infected fibroblasts.

Human fibroblasts weakly activated the alternative complement pathway, as assessed by C3b deposition, while 4- to 5-fold more C3b was observed 4 days after infection on cytomegalovirus (CMV)-infected fibroblasts when incubated with human serum. CMV-infected fibroblasts activated via the classical complement pathway independent of specific anti-CMV antibody and incubation of CMV-infected fibrobl...

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ژورنال

عنوان ژورنال: The Journal of Infectious Diseases

سال: 1998

ISSN: 0022-1899,1537-6613

DOI: 10.1086/314499